Lozenges for a Catarrh.
Take Spanish Juice of Liquorice 2 ounces; white Sugar 4 ounces; Opium 1 dram; beat all exactly well, so as to mix the Opium intimately and with Mucilage of Gum Tragacanth, form the Mass into Lozenges.
A dram of these contains about 1 grain of Opium, but great care must be taken in the well mixing of the Opium, that it lie not in Lumps.
Thomas Fuller
Pharmacopeia Extemporanea 1710